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Porcupine-IN-1
CAS No. 2036044-77-4
Porcupine-IN-1( Porcupine-IN-1 | MDK-4774 | MDK 4774 | MDK4774 )
Catalog No. M18214 CAS No. 2036044-77-4
Porcupine-IN-1 is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 107 | In Stock |
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| 5MG | 93 | In Stock |
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| 10MG | 155 | In Stock |
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| 25MG | 282 | In Stock |
|
| 50MG | 415 | In Stock |
|
| 100MG | 538 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePorcupine-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionPorcupine-IN-1 is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
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DescriptionMDK-4774, Porcupine-IN-1, is a Porcupine inhibitor.
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In VitroPorcupine is an enzyme that catalyses the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Porcupine-IN-1 is as potent as the clinical compound LGK974 in a cell based STF reporter gene assay. Porcn-IN-1 potently inhibits the secretion of Wnt3A, therefore is confirmed to be a porcupine inhibitor.
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In VivoPorcn-IN-1 demonstrates moderate clearance under the treatment of human liver microsomes (57 mL/min/kg) and rat liver microsomes (24 mL/min/kg). It exhibits high clearance when treated with mouse microsomes (109 mL/min/kg).
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SynonymsPorcupine-IN-1 | MDK-4774 | MDK 4774 | MDK4774
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PathwayOthers
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TargetOther Targets
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RecptorPorcupine
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number2036044-77-4
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Formula Weight410.44
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Molecular FormulaC25H19FN4O
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL; 243.64 mM
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SMILESCc1cc(ccn1)-c1ncc(CNC(=O)c2ccc3c(c2)[nH]c2ccccc32)cc1F
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Chemical NameN-((3-Fluoro-2’-methyl[2,4’-bipyridin]-5-yl)methyl)-9H-carbazole-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Xu Z, Xu X, O’Laoi R, et al. Bioorganic & medicinal chemistry, 2016, 24(22): 5861-5872.
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