Valepotriate( Valtrate )

Catalog No. M18145 CAS No. 18296-44-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Valepotriate
Note

Research use only, not for human use.
Brief Description

Valepotriate fraction can have sedative effects and affect behavioral parameters related to recognition memory.
Description

Valepotriate fraction can have sedative effects and affect behavioral parameters related to recognition memory. Valepotriates, a new class of cytotoxic and antitumor agents, they are very potent cytotoxic agents for the HTC hepatoma cells. Valepotriates may have a potential anxiolytic effect on the psychic symptoms of anxiety.
In Vitro

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In Vivo

Valepotriate?showed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50?values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore,?valepotriate?(10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore,?valepotriate?(5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB.
Synonyms

Valtrate
Pathway

Others
Target

Antioxidant
Recptor

HIV
Research Area

Others-Field
Indication

——

CAS Number

18296-44-1
Formula Weight

422.47
Molecular Formula

C22H30O8
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (236.70 mM)
SMILES

CC(C)CC(=O)O[C@H]3C=C1C(=CO[C@@H](OC(=O)CC(C)C)[C@@H]1[C@]23CO2)COC(C)=O
Chemical Name

[(1S,6S,7R,7aS)-4-(acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-methylbutanoate