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GSK-J4 Hydrochloride
CAS No. 1797983-09-5
GSK-J4 Hydrochloride( —— )
Catalog No. M18139 CAS No. 1797983-09-5
GSK-J4 is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with an IC50 value greater than 50 μM in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 135 | In Stock |
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| 2MG | 46 | In Stock |
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| 5MG | 77 | In Stock |
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| 10MG | 123 | In Stock |
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| 25MG | 218 | In Stock |
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| 50MG | 355 | In Stock |
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| 100MG | 523 | In Stock |
|
| 200MG | 730 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK-J4 Hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionGSK-J4 is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with an IC50 value greater than 50 μM in vitro.
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DescriptionGSK-J4 is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with an IC50 value greater than 50 μM in vitro.
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In Vitro——
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In VivoAnimal Model:Eight-week-old male db/m and db/db mice on a BKS background Dosage:10 mg/kg Administration:i.p.; thrice-weekly for 10 weeks Result:Attenuated the development of kidney disease in diabetic mice.
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Synonyms——
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PathwayApoptosis
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TargetPKA
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RecptorJMJD3
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1797983-09-5
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Formula Weight453.97
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Molecular FormulaC24H28ClN5O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (137.68 mM)
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SMILESCl.O=C(OCC)CCNc1cc(nc(n1)c2ccccn2)N3CCc4ccccc4CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yan N,etal.GSKJ4, an H3K27me3 demethylase inhibitor, effectively suppresses the breast cancer stem cells.Exp Cell Res. 2017 Oct 15;359(2):405-414.
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