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CGP 52432
CAS No. 139667-74-6
CGP 52432( Cgp 52432 | Cgp52432 | Cgp52432 )
Catalog No. M17994 CAS No. 139667-74-6
CGP52432 is a very potent antagonist of GABAB receptors (IC50 = 85 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 84 | In Stock |
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| 5MG | 75 | In Stock |
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| 10MG | 136 | In Stock |
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| 25MG | 255 | In Stock |
|
| 50MG | 365 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCGP 52432
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NoteResearch use only, not for human use.
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Brief DescriptionCGP52432 is a very potent antagonist of GABAB receptors (IC50 = 85 nM).
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DescriptionCgp 52432 is a GABA-A receptor antagonist.
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In VitroCGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM, 35- and 100-fold lower than at the receptors regulating somatostatin and glutamate overflow, respectively.
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In VivoCGP52432 (10, 30 mg/kg) shows no effect on the total arm entries and total head dips of mice on the elevated-plus maze. CGP52432 (100 nmol/kg, i.v., or 1 nmol/kg, i.c.v.) abolishes the suppressive effects of GABA ( 50 μmol/kg, i.v.) on enhanced renal sympathetic nerve activity (RSNA) during ischaemia, causeing elimination of the renoprotective effects of GABA in rats.
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SynonymsCgp 52432 | Cgp52432 | Cgp52432
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PathwayOthers
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TargetOther Targets
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RecptorGABAB
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number139667-74-6
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Formula Weight384.23
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Molecular FormulaC15H24Cl2NO4P
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Purity>98% (HPLC)
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SolubilityDMSO : 5 mg/mL 13.01 mM;
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SMILESCCOC(OCC)P(=O)(CCCNCC1=CC(=C(C=C1)Cl)Cl)O
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Chemical NamePhosphinic acid, (3-(((3,4-dichlorophenyl)methyl)amino)propyl)(diethoxymethyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bonanno G,etal.GABA(B) receptors as potential targets for drugs able to prevent excessive excitatory amino acid transmission in the spinal cord.Eur J Pharmacol. 1998 Dec 4;362(2-3):143-8.
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