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Home - Products - Metabolic Enzyme/Protease - Phosphatase - MHP

MHP

CAS No. 1104874-94-3

MHP( Defensamide | methyl caprooyl tyrosinate | MHP )

Catalog No. M17816 CAS No. 1104874-94-3

MHP is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 67 In Stock
2MG 38 In Stock
5MG 61 In Stock
10MG 103 In Stock
25MG 218 In Stock
50MG 346 In Stock
100MG 554 In Stock
200MG 788 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    MHP
  • Note
    Research use only, not for human use.
  • Brief Description
    MHP is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
  • Description
    Defensamide, also known as MHP and methyl caprooyl tyrosinate, is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
  • In Vitro
    MHP (50-250 μM for 24 hours) increases CAMP mRNA levels in keratinocytes.MHP (100 μM for 24 hours) increases CAMP protein levels in keratinocytes. TCell Viability Assay Cell Line:Keratinocytes Concentration:100 μM Incubation Time:24 hours Result:Increased CAMP protein levels in keratinocytes.
  • In Vivo
    ——
  • Synonyms
    Defensamide | methyl caprooyl tyrosinate | MHP
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    SphK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1104874-94-3
  • Formula Weight
    293.36
  • Molecular Formula
    C16H23NO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 100 mg/mL 340.88 mM; H2O : < 0.1 mg/mL
  • SMILES
    Oc1ccc(C[C@H](NC(=O)CCCCC)C(=O)OC)cc1
  • Chemical Name
    (S)-Methyl 2-(hexanamido)-3-(4-hydroxyphenyl)propanoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jeong SK, et al. Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production. J Dermatol Sci. 2015 Sep;79(3):229-34.
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