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MHP
CAS No. 1104874-94-3
MHP( Defensamide | methyl caprooyl tyrosinate | MHP )
Catalog No. M17816 CAS No. 1104874-94-3
MHP is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 67 | In Stock |
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| 2MG | 38 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 103 | In Stock |
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| 25MG | 218 | In Stock |
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| 50MG | 346 | In Stock |
|
| 100MG | 554 | In Stock |
|
| 200MG | 788 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMHP
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NoteResearch use only, not for human use.
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Brief DescriptionMHP is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
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DescriptionDefensamide, also known as MHP and methyl caprooyl tyrosinate, is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
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In VitroMHP (50-250 μM for 24 hours) increases CAMP mRNA levels in keratinocytes.MHP (100 μM for 24 hours) increases CAMP protein levels in keratinocytes. TCell Viability Assay Cell Line:Keratinocytes Concentration:100 μM Incubation Time:24 hours Result:Increased CAMP protein levels in keratinocytes.
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In Vivo——
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SynonymsDefensamide | methyl caprooyl tyrosinate | MHP
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PathwayMetabolic Enzyme/Protease
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TargetPhosphatase
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RecptorSphK
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Research Area——
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Indication——
Chemical Information
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CAS Number1104874-94-3
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Formula Weight293.36
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Molecular FormulaC16H23NO4
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL 340.88 mM; H2O : < 0.1 mg/mL
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SMILESOc1ccc(C[C@H](NC(=O)CCCCC)C(=O)OC)cc1
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Chemical Name(S)-Methyl 2-(hexanamido)-3-(4-hydroxyphenyl)propanoate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jeong SK, et al. Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production. J Dermatol Sci. 2015 Sep;79(3):229-34.
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