Nomilin

Research use only, not for human use.

Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.

Nomilin is an inducer of phase II detoxifying enzymes, showing anti-proliferative active on cultured human breast cancer cells.(In Vitro):Nomilin treatment significantly mitigated cell death and decreased lactate dehydrogenase (LDH) release and ROS production in SH-SY5Y cells induced by oxygen-glucose deprivation (OGD), which was almost abolished by Nrf2 knockdown.(In Vivo):Nomilin attenuated blood-brain barrier (BBB) disruption in MCAO rats, which might be associated with alleviating the loss of tight junction proteins, including ZO-1 and occludin-5.

Nomilin treatment significantly mitigated cell death and decreased lactate dehydrogenase (LDH) release and ROS production in SH-SY5Y cells induced by oxygen-glucose deprivation (OGD), which was almost abolished by Nrf2 knockdown.

Nomilin attenuated blood-brain barrier (BBB) disruption in MCAO rats, which might be associated with alleviating the loss of tight junction proteins, including ZO-1 and occludin-5.

Nomilin

Immunology/Inflammation

LTR

MAPK

Cancer

——

1063-77-0

514.57

C28H34O9

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (194.34 mM)

CC(=O)OC5CC(=O)O[C@@](C)(C)[C@@H]6CC(=O)[C@]3(C)[C@H](CC[C@@]2(C)[C@@H](OC(=O)[C@H]1O[C@]123)c4ccoc4)[C@@]56C

1-(Acetyloxy)-1,2-dihydroobacunoic acid e-lactone

(-20℃)

With Ice Pack

≥ 2 years