ANA-12( ANA12 | ANA 12 | ANA-12 )

Catalog No. M17439 CAS No. 219766-25-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ANA-12
Note

Research use only, not for human use.
Brief Description

ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.
Description

ANA-12 is aTrkB receptor antagonist. ANA-12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and TrkC functions. Systemic administration of ANA-12 to adult mice decreased TrkB activity in the brain without affecting neuronal survival. Mice administered ANA-12 demonstrated reduced anxiety- and depression-related behaviors on a variety of tests predictive of anxiolytic and antidepressant properties in humans. ANA-12 may be a valuable tool for studying BDNF/TrkB signaling and may constitute a lead compound for developing the next generation of therapeutic agents for the treatment of mood disorders.
In Vitro

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In Vivo

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Synonyms

ANA12 | ANA 12 | ANA-12
Pathway

Immunology/Inflammation
Target

LTR
Recptor

TrkB
Research Area

Neurological Disease
Indication

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CAS Number

219766-25-3
Formula Weight

407.49
Molecular Formula

C22H21N3O3S
Purity

>98% (HPLC)
Solubility

DMSO : 9.09 mg/mL. 22.31 mM;H2O : < 0.1 mg/mL
SMILES

O=C(Nc1ccccc1C(=O)NC1CCCCNC1=O)c1cc2ccccc2s1
Chemical Name

N-(2-((2-oxoazepan-3-yl)carbamoyl)phenyl)benzo[b]thiophene-2-carboxamide

1. Cazorla M, et al. J Clin Invest. 2011, 121(5), 1846-1857.

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