Vorapaxar sulfate( —— )

Catalog No. M17571 CAS No. 705260-08-8

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Vorapaxar sulfate
Note

Research use only, not for human use.
Brief Description

Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.
Description

Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.(In Vitro):Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM.
In Vitro

Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM.
In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

PAR-1
Research Area

——
Indication

——

CAS Number

705260-08-8
Formula Weight

590.66
Molecular Formula

C29H35FN2O8S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (211.63 mM)
SMILES

S(=O)(=O)(O)O.Fc1cc(c2cnc(/C=C/[C@@H]3[C@H]4[C@@H](C[C@H]5[C@H]3CC[C@@H](NC(=O)OCC)C5)C(=O)O[C@@H]4C)cc2)ccc1
Chemical Name

——

1. Chackalamannil S, et al. J Med Chem, 2008, 51(11), 3061-3064.

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