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Vorapaxar sulfate
CAS No. 705260-08-8
Vorapaxar sulfate( —— )
Catalog No. M17571 CAS No. 705260-08-8
Vorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 95 | In Stock |
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| 2MG | 43 | In Stock |
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| 5MG | 68 | In Stock |
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| 10MG | 116 | In Stock |
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| 25MG | 211 | In Stock |
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| 50MG | 346 | In Stock |
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| 100MG | 517 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1135 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVorapaxar sulfate
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NoteResearch use only, not for human use.
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Brief DescriptionVorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.
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DescriptionVorapaxar sulfate is a potent and orally active thrombin receptor (PAR-1) antagonist.(In Vitro):Vorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM.
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In VitroVorapaxar sulfate (SCH 530348 sulfate) shows potent inhibition of thrombin-induced platelet aggregation with an IC50 of 47 nM and haTRAP-induced platelet aggregation with an IC50 of 25 nM. Vorapaxar sulfate (SCH 530348 sulfate) inhibits thrombininduced calcium transient in human coronary artery smooth muscle cells (HCASMC) with a Ki of 1.1 nM. It also inhibits thrombin-stimulated thymidine incorporation in HCASMC with a Ki of 13 nM.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPAR-1
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Research Area——
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Indication——
Chemical Information
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CAS Number705260-08-8
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Formula Weight590.66
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Molecular FormulaC29H35FN2O8S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (211.63 mM)
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SMILESS(=O)(=O)(O)O.Fc1cc(c2cnc(/C=C/[C@@H]3[C@H]4[C@@H](C[C@H]5[C@H]3CC[C@@H](NC(=O)OCC)C5)C(=O)O[C@@H]4C)cc2)ccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chackalamannil S, et al. J Med Chem, 2008, 51(11), 3061-3064.
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