ICA069673

Research use only, not for human use.

ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).

ICA069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively). ICA-069673 inhibited spontaneous phasic, pharmacologically induced, and nerve-evoked contractions in DSM isolated strips in a concentration-dependent manner. ICA-069673 decreased the global intracellular Ca(2+) concentration in DSM cells, an effect blocked by the L-type Ca(2+) channel inhibitor nifedipine. ICA-069673 hyperpolarized the membrane potential and inhibited spontaneous action potentials of isolated DSM cells, effects that were blocked in the presence of XE991.

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ICA-069673 | ICA 069673 | ICA069673

Angiogenesis

FAK

KCNQ2/Q3 potassium channel

Neurological Disease

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582323-16-8

269.63

C11H6CLF2NO3

>98% (HPLC)

DMSO : ≥ 34 mg/mL; 126.10 mM

c1cc(c(cc1C(=O)Nc1cnc(nc1)Cl)F)F

N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-benzamide

(-20℃)

With Ice Pack

≥ 2 years