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ICA069673
CAS No. 582323-16-8
ICA069673( ICA-069673 | ICA 069673 | ICA069673 )
Catalog No. M17548 CAS No. 582323-16-8
ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 10MG | 46 | In Stock |
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| 25MG | 102 | In Stock |
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| 50MG | 178 | In Stock |
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| 100MG | 259 | In Stock |
|
| 200MG | 375 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameICA069673
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NoteResearch use only, not for human use.
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Brief DescriptionICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).
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DescriptionICA069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively). ICA-069673 inhibited spontaneous phasic, pharmacologically induced, and nerve-evoked contractions in DSM isolated strips in a concentration-dependent manner. ICA-069673 decreased the global intracellular Ca(2+) concentration in DSM cells, an effect blocked by the L-type Ca(2+) channel inhibitor nifedipine. ICA-069673 hyperpolarized the membrane potential and inhibited spontaneous action potentials of isolated DSM cells, effects that were blocked in the presence of XE991.
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In Vitro——
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In Vivo——
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SynonymsICA-069673 | ICA 069673 | ICA069673
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PathwayAngiogenesis
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TargetFAK
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RecptorKCNQ2/Q3 potassium channel
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number582323-16-8
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Formula Weight269.63
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Molecular FormulaC11H6CLF2NO3
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 34 mg/mL; 126.10 mM
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SMILESc1cc(c(cc1C(=O)Nc1cnc(nc1)Cl)F)F
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Chemical NameN-(2-chloro-5-pyrimidinyl)-3,4-difluoro-benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wickenden AD, et al. Mol Pharmacol. 2008 Mar;73(3):977-86. Epub 2007 Dec 18.
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