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NSC 207895
CAS No. 58131-57-0
NSC 207895( —— )
Catalog No. M17547 CAS No. 58131-57-0
NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 110 | In Stock |
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| 2MG | 70 | In Stock |
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| 5MG | 116 | In Stock |
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| 10MG | 187 | In Stock |
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| 25MG | 432 | In Stock |
|
| 50MG | 625 | In Stock |
|
| 100MG | 889 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1786 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNSC 207895
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NoteResearch use only, not for human use.
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Brief DescriptionNSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
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DescriptionNSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
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In VitroWestern Blot Analysis Cell Line:RAW 264.7 cells.Concentration:0.5 μM.Incubation Time:30 min (stimulated with LPS (100 ng/ml) for 6 h).Result:Upregulated p53 protein levels.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetP450
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Recptorp53 , MDMX
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Research Area——
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Indication——
Chemical Information
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CAS Number58131-57-0
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Formula Weight279.25
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Molecular FormulaC11H13N5O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 31.25 mg/mL (111.91 mM)
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SMILESCN1CCN(CC1)C2=CC=C(C3=NO[N+](=C23)[O-])[N+](=O)[O-]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang H, et al. Mol Cancer Ther, 2011, 10(1), 69-79.
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