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Home - Products - Cell Cycle/DNA Damage - GPR - SR-4370

SR-4370

CAS No. 1816294-67-3

SR-4370( SR-4370 | SR 4370 | SR4370 )

Catalog No. M17385 CAS No. 1816294-67-3

SR- 4370 is an HDAC inhibitor. SR- 4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SR-4370
  • Note
    Research use only, not for human use.
  • Brief Description
    SR- 4370 is an HDAC inhibitor. SR- 4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3.
  • Description
    SR- 4370 is an HDAC inhibitor. SR- 4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. SR- 4370 is reported in WO 2015153516.
  • In Vitro
    SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. SR-4370 is cytotoxic to the breast cancer cells (MDA-MB-231), with an IC50 of 12.6 μM.
  • In Vivo
    ——
  • Synonyms
    SR-4370 | SR 4370 | SR4370
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    HDAC1| HDAC2| HDAC3
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1816294-67-3
  • Formula Weight
    304.34
  • Molecular Formula
    C17H18F2N2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 150 mg/mL; 492.89 mM
  • SMILES
    Fc1c(cccc1F)c2ccc(cc2)C(=O)NNCCCC
  • Chemical Name
    N'-butyl-2',3'-difluoro-[1,1'-biphenyl]-4-carbohydrazide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. D Liao, etal. HDAC Inhibitor Compounds and Methods of Treatment
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