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RO 46-8443

CAS No. 175556-12-4

RO 46-8443( RO 46-8443 | RO46-8443 | RO-46-8443 | RO 468443 )

Catalog No. M17374 CAS No. 175556-12-4

RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RO 46-8443
  • Note
    Research use only, not for human use.
  • Brief Description
    RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition.
  • Description
    RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. The observed parallel rightward shift of concentration-response curves with different antagonist concentrations is consistent with a competitive binding mode. Since R0 46-8443 selectively inhibits ETB receptor mediated responses, it is a valuable tool for clarifying the role of ETB receptors in pathology.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RO 46-8443 | RO46-8443 | RO-46-8443 | RO 468443
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    ET-B
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    175556-12-4
  • Formula Weight
    609.69
  • Molecular Formula
    C31H35N3O8S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (410.04 mM)
  • SMILES
    c1(ccc(cc1)C(C)(C)C)S(=O)(=O)Nc1nc(nc(c1Oc1c(cccc1)OC)OC[C@@H](CO)O)c1ccc(cc1)OC
  • Chemical Name
    4-(tert-butyl)-N-(6-(2,3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Guimar?es CL, Trentin PG, Rae GA. Endothelin ET(B) receptor-mediated mechanisms involved in oleic acid-induced acute lung injury in mice. Clin Sci (Lond). 2002 Aug;103 Suppl 48:340S-344S.
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