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Hydroxyfasudil Hydrochloride
CAS No. 155558-32-0
Hydroxyfasudil Hydrochloride( HA-1100 hydrochloride | HA 1100 hydrochloride )
Catalog No. M17334 CAS No. 155558-32-0
Hydroxyfasudil hydrochloride is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 31 | In Stock |
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| 5MG | 50 | In Stock |
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| 10MG | 76 | In Stock |
|
| 25MG | 114 | In Stock |
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| 50MG | 140 | In Stock |
|
| 100MG | 259 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameHydroxyfasudil Hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionHydroxyfasudil hydrochloride is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
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DescriptionHydroxyfasudil hydrochloride is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
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In VitroHydroxyfasudil hydrochloride is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively. Hydroxyfasudil also less potently inhibits PKA, with an IC50 of 37 μM, 50-fold higher than those of the ROCKs. Hydroxyfasudil increases eNOS mRNA levels, with an EC50 value of 0.8 ± 0.3 μM. Hydroxyfasudil (0-100 μM) concentration-dependently increases eNOS activity and stimulates NO production in human aortic endothelial cells (HAEC). Hydroxyfasudil (10 μM) increases the half-life of eNOS mRNA from 13 to 16 hours, but does not affect eNOS promoter activity at concentrations from 0.1 to 100 μM.
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In VivoHydroxyfasudil (10 mg/kg, i.p.) significantly increases both the average and maximal voided volumes in SD rats. Hydroxyfasudil also significantly decreases the maximal detrusor pressure. Hydroxyfasudil (3 mg/kg, i.p) inhibits hypercontractility induced by norepinephrine in spontaneously hypertensive rats (SHRs). Furthermore, Hydroxyfasudil (3, 10 mg/kg, i.p) significantly ameliorates decreased penile cGMP contents in rats.
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SynonymsHA-1100 hydrochloride | HA 1100 hydrochloride
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PathwayMetabolic Enzyme/Protease
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TargetPPAR
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RecptorROCK
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number155558-32-0
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Formula Weight343.83
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Molecular FormulaC14H18ClN3O3S
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Purity>98% (HPLC)
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SolubilityDMSO : 30 mg/mL. 87.25 mM;
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SMILESC1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CNC3=O.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Rikitake Y, et al. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke. 2005 Oct;36(10):2251-7. Epub 2005 Sep 1.
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