TG6-10-1( TG6-10-1 | TG 6-10-1 | TG-6-10-1 | TP6101 )

Catalog No. M17283 CAS No. 1415716-58-3

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Datasheet

HNMR

HPLC

MSDS

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Product Name

TG6-10-1
Note

Research use only, not for human use.
Brief Description

TG6-10-1 is an EP2 antagonist.
Description

TG6-10-1 is a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2. Systemic administration of TG6-10-1 completely recapitulates the effects of conditional ablation of cyclooxygenase-2 from principal forebrain neurons, namely reduced delayed mortality, accelerated recovery from weight loss, reduced brain inflammation, prevention of blood-brain barrier opening, and neuroprotection in the hippocampus, without modifying seizures acutely. TG6-10-1 shows low-nanomolar antagonist activity against EP2.
In Vitro

TG6-10-1 robustly blocks prostaglandin E2 (PGE2) (10 μM)-induced cAMP accumulation in a concentration-dependent manner in SH-SY5Y cells.
In Vivo

TG6-10-1 (5 mg/kg; i.p.; 4-30 hours) improves survival, accelerates recovery of lost weight, and improves functional recovery following status epilepticus (SE) . Animal Model:C57BL/6 mice (pilocarpine-induced SE)Dosage:5 mg/kg Administration:Intraperitoneal injection; 4, 21, 30 hours Result:A significant increase in survival and accelerating the recovery of lost weight in post-SE mice.
Synonyms

TG6-10-1 | TG 6-10-1 | TG-6-10-1 | TP6101
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

5-HT2B
Research Area

Neurological Disease
Indication

——

CAS Number

1415716-58-3
Formula Weight

448.43
Molecular Formula

C23H23F3N2O4
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 100 mg/mL; 223.00 mM
SMILES

C(=O)(/C=C/c1cc(c(c(c1)OC)OC)OC)NCCn1c(cc2ccccc12)C(F)(F)F
Chemical Name

(E)-N-(2-(2-(trifluoromethyl)-1H-indol-1-yl)ethyl)-3-(3,4,5-trimethoxyphenyl)acrylamide

1. Jiang J, et al. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3591-3596.

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