QNZ46( QNZ46 | QNZ-46 | QNZ 46 )

Catalog No. M17213 CAS No. 1237744-13-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

QNZ46
Note

Research use only, not for human use.
Brief Description

QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.
Description

QNZ46 is a NMDA receptor antagonist. QNZ46 inhibits NMDA receptor function in a noncompetitive and voltage-independent manner by an unconventional mechanism that requires binding of glutamate to the GluN2 subunit, but not glycine binding to the GluN1 subunit. QNZ46 could provide an opportunity for the development of pharmacological tools and therapeutic agents that target NMDA receptors at a new site and modulate function by a novel mechanism. NMDA receptors are ionotropic glutamate receptors that mediate excitatory synaptic transmission and have been implicated in several neurological diseases.
In Vitro

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In Vivo

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Synonyms

QNZ46 | QNZ-46 | QNZ 46
Pathway

MAPK/ERK Signaling
Target

MEK
Recptor

NR2A| NR2C| NR2D
Research Area

Neurological Disease
Indication

——

CAS Number

1237744-13-6
Formula Weight

443.41
Molecular Formula

C24H17N3O6
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 4.5 mg/mL10.15 mM
SMILES

COc1cc2c(cc1)nc(n(c2=O)c1ccc(cc1)C(=O)O)/C=C/c1cc(ccc1)[N+](=O)[O-]
Chemical Name

(E)-4-(6-methoxy-2-(3-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)benzoic acid

1. Hansen KB, et al. J Neurosci. 2011 Mar 9;31(10):3650-3661.

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