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MLN0905
CAS No. 1228960-69-7
MLN0905( MLN0905 | MLN 0905 | MLN-0905 )
Catalog No. M17207 CAS No. 1228960-69-7
MLN0905 is an effective PLK1 inhibitor(IC50=2 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 131 | In Stock |
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| 5MG | 123 | In Stock |
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| 10MG | 188 | In Stock |
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| 25MG | 351 | In Stock |
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| 50MG | 516 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMLN0905
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NoteResearch use only, not for human use.
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Brief DescriptionMLN0905 is an effective PLK1 inhibitor(IC50=2 nM).
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DescriptionMLN0905 is a potent, selective small-molecule PLK1 inhibitor. MLN0905 inhibits cell proliferation in a broad range of human tumor cells including DLBCL cell lines. PLK1 inhibition leads to pharmacodynamic pHisH3 modulation and significant antitumor activity in multiple DLBCL models. These data strongly suggest evaluating PLK1 inhibitors as DLBCL anticancer agents in the clinic. (source: Mol Cancer Ther; 11(9); 2045-53.)
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In Vitro——
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In VivoAnimal Model:Tumor (HT29) xenograft modelDosage:0-50 mg/kg Administration:P.O; daily, QD×3/week Result:Observed antitumor activity, tumor stasis or regression and well-tolerated oral doses.
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SynonymsMLN0905 | MLN 0905 | MLN-0905
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PathwayMetabolic Enzyme/Protease
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TargetFactor Xa
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RecptorPLK1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1228960-69-7
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Formula Weight486.56
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Molecular FormulaC24H25F3N6S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 30 mg/mL. 61.66 mM
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SMILESCN(C)CCCc1cc(Nc2ncc3CC(=S)Nc4c(ccc(c4)C(F)(F)F)c3n2)c(C)nc1
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Chemical Name2-((5-(3-(dimethylamino)propyl)-2-methylpyridin-3-yl)amino)-9-(trifluoromethyl)-5H-benzo[b]pyrimido[4,5-d]azepine-6(7H)-thione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Duffey MO, et al. J Med Chem, 2012, 55(1), 197-208.
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