Skepinone-L( Skepinone-L )

Catalog No. M17201 CAS No. 1221485-83-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Skepinone-L
Note

Research use only, not for human use.
Brief Description

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
Description

Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 μM).
In Vitro

Skepinone-L (CBS3830),the first ATP-competitive p38 MAPK inhibitor with excellent in vivo efficacy and selectivity. Therefore, Skepinone-L (CBS3830) is a valuable probe for chem. biol. research, and it may foster the development of a unique class of kinase inhibitors.
In Vivo

——
Synonyms

Skepinone-L
Pathway

Metabolic Enzyme/Protease
Target

Dehydrogenase
Recptor

p38α
Research Area

Inflammation/Immunology
Indication

——

CAS Number

1221485-83-1
Formula Weight

425.42
Molecular Formula

C24H21F2NO4
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 50 mg/mL 117.53 mM; H2O : < 0.1 mg/mL
SMILES

c12c(C(=O)c3c(CC1)ccc(c3)OC[C@@H](CO)O)ccc(c2)Nc1c(cc(cc1)F)F
Chemical Name

2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one

1. Koeberle SC, et al. Nat Chem Biol. 2011, 8(2), 141-143.

Calculator

molnova catalog