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GLPG0634 analogue

CAS No. 1206101-20-3

GLPG0634 analogue( Filgotinib-analogue, GLPG0634-analogue )

Catalog No. M17191 CAS No. 1206101-20-3

GLPG0634 (analog) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 85 In Stock
2MG 46 In Stock
5MG 76 In Stock
10MG 140 In Stock
25MG 263 In Stock
50MG 456 In Stock
100MG 644 In Stock
200MG Get Quote In Stock
500MG 1349 In Stock
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Biological Information

  • Product Name
    GLPG0634 analogue
  • Note
    Research use only, not for human use.
  • Brief Description
    GLPG0634 (analog) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.
  • Description
    GLPG0634-analogue is an analogue of Filgotinib or GLPG0634, is a potent and selective JAK1 inhibitor.
  • In Vitro
    GLPG0634 analog (Compoun 176) inhibits JAK-STAT signaling and OSM/IL-lβ signaling with both EC50 values of 101-500 nM.GLPG0634 analog shows microsomal stability of 76%-100% in rat and human.
  • In Vivo
    ——
  • Synonyms
    Filgotinib-analogue, GLPG0634-analogue
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    JAK1| JAK2| JAK3
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    1206101-20-3
  • Formula Weight
    425.5
  • Molecular Formula
    C21H23N5O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 53 mg/mL 129.13 mM
  • SMILES
    O=C(C1CC1)Nc1nn2c(c3ccc(OCc4ccc(C#N)nc4)cc3)cccc2n1
  • Chemical Name
    N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Van Rompaey L, et al. J Immunol. 2013, 191(7), 3568-3577.
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