GLPG0634 analogue( Filgotinib-analogue, GLPG0634-analogue )

Catalog No. M17191 CAS No. 1206101-20-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GLPG0634 analogue
Note

Research use only, not for human use.
Brief Description

GLPG0634 (analog) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.
Description

GLPG0634-analogue is an analogue of Filgotinib or GLPG0634, is a potent and selective JAK1 inhibitor.
In Vitro

GLPG0634 analog (Compoun 176) inhibits JAK-STAT signaling and OSM/IL-lβ signaling with both EC50 values of 101-500 nM.GLPG0634 analog shows microsomal stability of 76%-100% in rat and human.
In Vivo

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Synonyms

Filgotinib-analogue, GLPG0634-analogue
Pathway

Neuroscience
Target

GluR
Recptor

JAK1| JAK2| JAK3
Research Area

Inflammation/Immunology
Indication

——

CAS Number

1206101-20-3
Formula Weight

425.5
Molecular Formula

C21H23N5O3S
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 53 mg/mL 129.13 mM
SMILES

O=C(C1CC1)Nc1nn2c(c3ccc(OCc4ccc(C#N)nc4)cc3)cccc2n1
Chemical Name

N-[5-[4-[(6-Cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxamide

1. Van Rompaey L, et al. J Immunol. 2013, 191(7), 3568-3577.

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