B-Raf inhibitor 1 dihydrochloride( B-Raf inhibitor 1 dihydrochloride )

Catalog No. M17180 CAS No. 1191385-19-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

B-Raf inhibitor 1 dihydrochloride
Note

Research use only, not for human use.
Brief Description

B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor.
Description

B-Raf inhibitor 1 dihydrochloride is a novel potent and selective B-Raf inhibitor.
In Vitro

B-Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC50s of 0.31 and 0.72 μM, respectively. B-Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. B-Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers.
In Vivo

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Synonyms

B-Raf inhibitor 1 dihydrochloride
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Akt
Recptor

B-Raf
Research Area

Cancer
Indication

——

CAS Number

1191385-19-9
Formula Weight

478.94
Molecular Formula

C26H19ClN8
Purity

>98% (HPLC)
Solubility

——
SMILES

Cc1c(c2c(cc1)c(ncc2)Nc1ccc(cc1)Cl)Nc1c(cccn1)c1c2c(ncn1)nc[nH]2.Cl.Cl
Chemical Name

1-N-(4-Chlorophenyl)-6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine dihydrochloride

1. Wang X, et al. J Med Chem. 2012 Sep 13;55(17): 7332-41.

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