GSK0660( GSK0660 | GSK-0660 | GSK 0660 )

Catalog No. M17116 CAS No. 1014691-61-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK0660
Note

Research use only, not for human use.
Brief Description

GSK0660 is an antagonist and inverse agonist of PPARβ/δ.
Description

GSK0660 is a selective PPARδ antagonist. GSK0660 differentially regulated 273 transcripts in TNFα-treated cells compared to TNFα alone. A pathway analysis revealed the enrichment of cytokine-cytokine receptor signaling. In particular, GSK0660 blocks the TNFα-induced upregulation of CCL8, a chemokine involved in leukocyte recruitment. GSK0660 blocks the effect of TNFα on the expressions of cytokines involved in leukocyte recruitment, including CCL8, CCL17, and CXCL10 and it may therefore block TNFα-induced retinal leukostasis.
In Vitro

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In Vivo

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Synonyms

GSK0660 | GSK-0660 | GSK 0660
Pathway

Neuroscience
Target

GluR
Recptor

PPARβ| PPARδ
Research Area

Others-Field
Indication

——

CAS Number

1014691-61-2
Formula Weight

418.49
Molecular Formula

C19H18N2O5S2
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 49 mg/mL 117.09 mM
SMILES

COc1c(ccc(c1)Nc1ccccc1)NS(=O)(=O)c1c(scc1)C(=O)OC
Chemical Name

methyl 3-(N-(2-methoxy-4-(phenylamino)phenyl)sulfamoyl)thiophene-2-carboxylate

1. Savage SR, et al. Mol Vis. 2015 May 20;21:568-76.

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