DIMP53-1( —— )

Catalog No. M17082 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DIMP53-1
Note

Research use only, not for human use.
Brief Description

A novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53.
Description

A novel small-molecule dual inhibitor of p53-MDM2/X interactions by potentially binding to p53, without effect on other MDM; causes growth inhibition, mediated by p53 stabilization and upregulation of p53 transcriptional targets involved in cell cycle arrest and apoptosis; shows a p53-dependent antitumor activity in human tumor xenograft mice models; a novel p53 activator.
In Vitro

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In Vivo

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Synonyms

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Pathway

Apoptosis
Target

MDM2-p53
Recptor

MDM2-p53
Research Area

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Indication

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CAS Number

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Formula Weight

408.501
Molecular Formula

C27H24N2O2
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C1N2[C@@](OC[C@@H]2CC3=CN(CC4=CC=CC=C4)C5=C3C=CC=C5)(C)C6=C1C=CC=C6
Chemical Name

(3S,9bR)-3-((1-benzyl-1H-indol-3-yl)methyl)-9b-methyl-2,3-dihydrooxazolo[2,3-a]isoindol-5(9bH)-one

1. Soares J, et al. Mol Oncol. 2017 Jun;11(6):612-627.

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