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ML379
CAS No. 1630760-58-5
ML379( CID71576758 )
Catalog No. M12450 CAS No. 1630760-58-5
ML379 (CID71576758) is a potent, selective TP53 mutant cancer cells inhibitor with IC50 of 13 nM in sensitive HeLa cells (TP53 mutant).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameML379
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NoteResearch use only, not for human use.
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Brief DescriptionML379 (CID71576758) is a potent, selective TP53 mutant cancer cells inhibitor with IC50 of 13 nM in sensitive HeLa cells (TP53 mutant).
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DescriptionML379 (CID71576758) is a potent, selective TP53 mutant cancer cells inhibitor with IC50 of 13 nM in sensitive HeLa cells (TP53 mutant); displays >1,000-fold selectivity over insensitive A549 cells (TP53 wild type); displays low nM activity in a larger panel of TP53 mutant cell lines.
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In Vitro——
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In Vivo——
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SynonymsCID71576758
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research Area——
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Indication——
Chemical Information
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CAS Number1630760-58-5
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Formula Weight273.33
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Molecular FormulaC15H19N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(R)-5-Methyl-6-(4-morpholinophenyl)-4,5-dihydropyridazin-3(2H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lewis TA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
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