MC 2494( MC2494 )

Catalog No. M17073 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MC 2494
Note

Research use only, not for human use.
Brief Description

MC 2494 is a nove potent, pan-Sirtuin (SirT) inhibitor.
Description

MC 2494 is a nove potent, pan-Sirtuin (SirT) inhibitor, increases RIP1 acetylation in the death domain and induces bona fide tumour-restricted acetylated RIP1/caspase-8-mediated apoptosis; displays tumour-selective potential in vitro, in leukemic blasts ex vivo, and in vivo in both xenograft and allograft cancer models; also displays tumour-preventive activity by blocking DMBA-induced mammary gland hyper-proliferation in vivo.
In Vitro

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In Vivo

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Synonyms

MC2494
Pathway

Chromatin/Epigenetic
Target

Sirtuin
Recptor

Sirtuin
Research Area

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Indication

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CAS Number

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Formula Weight

426.86
Molecular Formula

C24H15ClN4O2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(E)-3-(4-(2-chlorobenzoyl)-1H-pyrrol-2-yl)-2-cyano-N-(quinolin-5-yl)acrylamide

1. Altucci L, et al. Clin Cancer Res. 2018 Mar 13. pii: clincanres.3081.2017.

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