MP-HJ-1b

Research use only, not for human use.

MP-HJ-1b is a novel potent inhibitor of microtubule and tumor cell growth.

MP-HJ-1b is a novel potent inhibitor of microtubule and tumor cell growth, binds the colchicine pocket at the intra-dimer interface, depolymerizes microtubules and affects spindle formation; shows activities against a panel of more than 1000 human cancer cell lines with a wide variety of tissue origins, also induces the spike-like conformation of microtubules in vitro and in vivo, which is different from typical microtubule modulators; exhibits an interesting property of general cytotoxicity instead of Ras-mutant-specific killing (A549 KRAS-G12S, IC50=0.04 uM); MPHJ-1b displayed favorable pharmacological properties for overcoming tumor MDR both in vitro and in vivo.

——

——

——

Cytoskeleton/Cell Adhesion Molecules

Microtubule/Tubulin

Microtubule/Tubulin

——

——

——

373.43

C21H15N3O2S

>98% (HPLC)

——

——

N-(2-(benzofuran-2-yl)benzyl)-4H-pyrrolo[2,3-d]thiazole-5-carboxamide

(-20℃)

With Ice Pack

≥ 2 years