BAY-885( BAY885 )

Catalog No. M16999 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BAY-885
Note

Research use only, not for human use.
Brief Description

BAY-885 (BAY885) is a highly potent, selective ERK5 (MAPK7) inhibitor with IC50 of 40 nM.
Description

BAY-885 (BAY885) is a highly potent, selective ERK5 (MAPK7) inhibitor with IC50 of 40 nM, shows high selectivity over a panel of 357 kinases (Eurofins panel); strongly inhibits EGF-stimulated MEF2 transcriptional activity in MEF2 reporter assay with IC50 of 115 nM; despite its high potency, BAY-885 failed to inhibit the proliferation of cells with ERK5 genomic amplification (SN12C, SNU-449, MFM-223) or with constitutively active ERK5 signaling (BT-474, SK-BR-3).
In Vitro

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In Vivo

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Synonyms

BAY885
Pathway

MAPK/ERK Signaling
Target

ERK
Recptor

ERK
Research Area

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Indication

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CAS Number

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Formula Weight

515.541
Molecular Formula

C25H28F3N7O2
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(C1=CC=C(OC(F)(F)F)C=C1N)N2CCC(C3=C4C(C=C(N5CCN(C)CC5)C=N4)=NC=N3)CC2
Chemical Name

(2-amino-4-(trifluoromethoxy)phenyl)(4-(7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl)piperidin-1-yl)methanone

1. Clara Lemos, et al. Abstract 5866: Discovery and profiling of a highly potent and selective ERK5 inhibitor: BAY-885. AACR. 2018.

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