MEKK2 inhibitor 1s( MEKK2-IN-1s )

Catalog No. M16998 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MEKK2 inhibitor 1s
Note

Research use only, not for human use.
Brief Description

MEKK2 inhibitor 1s (MEKK2-IN-1s) is a potent MEKK2 (MAP3K2) inhibitor with IC50 of 16 nM, inhibits MEKK2 and MEKK3 with similar potencies.
Description

MEKK2 inhibitor 1s (MEKK2-IN-1s) is a potent MEKK2 (MAP3K2) inhibitor with IC50 of 16 nM, inhibits MEKK2 and MEKK3 with similar potencies; displays activity in cell-based assays in which it inhibited ERK5 pathway activation in cells and inhibited cell migration in a scratch assay.
In Vitro

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In Vivo

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Synonyms

MEKK2-IN-1s
Pathway

MAPK/ERK Signaling
Target

MEK
Recptor

MEK
Research Area

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Indication

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CAS Number

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Formula Weight

338.363
Molecular Formula

C19H18N2O4
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(Z)-8-ethoxy-2-((4-hydroxy-2-methylphenyl)imino)-2H-chromene-3-carboxamide

1. Ahmad S, et al. Biochem Biophys Res Commun. 2018 Jan 29;496(1):205-211.

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