MMK7 inhibitor 4a( —— )

Catalog No. M16995 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MMK7 inhibitor 4a
Note

Research use only, not for human use.
Brief Description

MMK7 inhibitor 4a is a potent, sepecific, covalent inhibitor of MMK7.
Description

MMK7 inhibitor 4a is a potent, sepecific, covalent inhibitor of MMK7, displays >800-fold selectivity over EGFR-WT and EGFR-L858R/T790M; MMK7 inhibitor 4a formed a covalent bond to Cys218 at the end of the hinge region of MMK7; displayed an excellent selectivity profile at 1 uM against a panel of 320 kinases; potently inhibits cellular JNK at 1 uM and completely inhibited its downstream effector c-Jun with no effect on the JNK-pathway; MMK7 inhibitor 4a is a valuable probe for further investigation to elucidate the function of MKK7 in cellular studies and in vivo.
In Vitro

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In Vivo

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Synonyms

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Pathway

MAPK/ERK Signaling
Target

MEK
Recptor

MEK
Research Area

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Indication

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CAS Number

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Formula Weight

456.51
Molecular Formula

C24H24N8O2
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

(R)-1-(3-(5-(1-(4-acetylphenyl)-1H-1,2,3-triazol-4-yl)-4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)piperidin-1-yl)prop-2-en-1-one

1. Wolle P, et al. J Med Chem. 2019 Feb 15. doi: 10.1021/acs.jmedchem.9b00102.

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