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KRAS inhibitor C6ME
CAS No. ——
KRAS inhibitor C6ME( —— )
Catalog No. M16989 CAS No. ——
KRAS inhibitor C6ME is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameKRAS inhibitor C6ME
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NoteResearch use only, not for human use.
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Brief DescriptionKRAS inhibitor C6ME is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V in vitro.
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DescriptionKRAS inhibitor C6ME is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V in vitro.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetRas
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RecptorRas
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight377.488
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Molecular FormulaC23H27N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Namemethyl 3-((((2S,4R)-2-benzylpiperidin-4-yl)amino)methyl)-1H-indole-6-carboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fang Z, et al. Cell Chem Biol. 2018 Aug 14. pii: S2451-9456(18)30261-7.
2. Jansen JM, et al. PLoS One. 2017 Apr 6;12(4):e0174706.
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SAH-SOS1A
KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.
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KRas-IN-1
A chemical fragment hit that binds to K-Ras (G12D) with affinities of 1.3-2 mM.
