SOS1 activator 17( —— )

Catalog No. M13563 CAS No. 2228955-02-8

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Datasheet

HNMR

HPLC

MSDS

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Product Name

SOS1 activator 17
Note

Research use only, not for human use.
Brief Description

SOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM.
Description

SOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM, modulates RAS signaling in vitro; activates the nucleotide exchange process at submicromolar concentrations in vitro, increases levels of active RAS-GTP in HeLa cells, and elicits signaling changes in the MAPK-ERK pathway, resulting in a decrease in pERK1/2T202/Y204 protein levels.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

Ras
Recptor

Ras
Research Area

——
Indication

——

CAS Number

2228955-02-8
Formula Weight

496.436
Molecular Formula

C26H27Cl2N5O
Purity

>98% (HPLC)
Solubility

——
SMILES

C1C2CN(CC2CN1CC3=CNC4=C3C=C(C=C4)Cl)C(=O)C(CC5=CNC6=C5C=CC(=C6)Cl)N
Chemical Name

(2S)-2-Amino-3-(6-chloro-1H-indol-3-yl)-1-(5-((5-chloro-1H-indol-3-yl)methyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propan-1-one

1. Abbott JR, et al. J Med Chem. 2018 Jul 11. doi: 10.1021/acs.jmedchem.8b00360.

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