RAS inhibitor Abd-7( —— )

Catalog No. M16987 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RAS inhibitor Abd-7
Note

Research use only, not for human use.
Brief Description

RAS inhibitor Abd-7 is a potent RAS-binding compound (Kd=51 nM) that interacts with RAS in cells.
Description

RAS inhibitor Abd-7 is a potent RAS-binding compound (Kd=51 nM) that interacts with RAS in cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signalling; impairs the protein-protein interaction (PPI) of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRASQ61H and HRASG12V, inhibits phosphorylation of both downstream biomarkers in colorectal cancer (DLD-1, KRASG13D) and NSCLC (H538, KRASG12C) human cell lines, with reduction of AKT phosphorylation starting at 2 uM; shows consistent inhibitory effects in the cell-based BRET assay and the biomarker assay.
In Vitro

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In Vivo

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Synonyms

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Pathway

MAPK/ERK Signaling
Target

Ras
Recptor

Ras
Research Area

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Indication

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CAS Number

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Formula Weight

391.471
Molecular Formula

C23H25N3O3
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

6-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-N-(4-((dimethylamino)methyl)phenyl)-2-methoxypyridin-3-amine

1. Quevedo CE, et al. Nat Commun. 2018 Aug 9;9(1):3169.

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