JTT-551 sodium( JTT551 | JTT 551 )

Catalog No. M16964 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

JTT-551 sodium
Note

Research use only, not for human use.
Brief Description

JTT-551 sodium (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM.
Description

JTT-551 sodium (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR; JTT-551 exhibits clear selectivity against the other PTPs, increases the insulin-stimulated glucose uptake in L6 cells; enhances the IR phosphorylation of liver and reduces the glucose level in ob/ob mice , also shows a hypoglycaemic effect without an acceleration of body weight gain in db/db mice.Diabetes Phase 1 Discontinued.
In Vitro

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In Vivo

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Synonyms

JTT551 | JTT 551
Pathway

Metabolic Enzyme/Protease
Target

Protein Phosphatase/PTP
Recptor

Protein Phosphatase/PTP
Research Area

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Indication

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CAS Number

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Formula Weight

628.846
Molecular Formula

C34H43N3NaO3S2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

N-((5-(tert-butyl)thiazol-2-yl)methyl)-N-((4-(4-((4-(heptan-4-yl)phenoxy)methyl)phenyl)thiazol-2-yl)methyl)glycine, sodium salt

1. Fukuda S, et al. Diabetes Obes Metab. 2010 Apr;12(4):299-306. 2. Ito M, et al. J Diabetes Res. 2014;2014:680348.

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