CDK12 inhibitor 2( —— )

Catalog No. M16942 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

CDK12 inhibitor 2
Note

Research use only, not for human use.
Brief Description

CDK12 inhibitor 2 is a potent, selective, non-covalent CDK12 inhibitor with IC50 of 52 nM, displays >192-fold selectivity over CDK2/7/8/9.
Description

CDK12 inhibitor 2 is a potent, selective, non-covalent CDK12 inhibitor with IC50 of 52 nM, displays >192-fold selectivity over CDK2/7/8/9; also potently inhibitor CDK13 with IC50 of 10 nM; inhibits the phosphorylation of Ser2 in the C-terminal domain (CTD) of RNA polymerase II in SK-BR-3 cells at low submicromolar concentrations (iC50=0.195 uM), inhibits the growth of SK-BR-3 cells with IC50 of 0.8 uM.
In Vitro

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In Vivo

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Synonyms

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Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

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Indication

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CAS Number

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Formula Weight

532.648
Molecular Formula

C32H32N6O2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

3-benzyl-1-((1r,4r)-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-(4-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)phenyl)urea

1. Ito M, et al. J Med Chem. 2018 Aug 1. doi: 10.1021/acs.jmedchem.8b00683.

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