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SCF-I2

CAS No. 99827-46-0

SCF-I2( SCF I2 )

Catalog No. M16917 CAS No. 99827-46-0

An allosteric, sepecific inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase with IC50 of 6.2 uM in FP assyas.

Purity : >98% (HPLC)

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HPLC

MSDS

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Biological Information

Product Name

SCF-I2
Note

Research use only, not for human use.
Brief Description

An allosteric, sepecific inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase with IC50 of 6.2 uM in FP assyas.
Description

An allosteric, sepecific inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase with IC50 of 6.2 uM in FP assyas; does not affect the activity of the closely related E3 enzyme SCFMet30, inhibits binding and/or ubiquitination of both full length Sic1 and Far1 with IC50 of 60 uM.
In Vitro

——
In Vivo

——
Synonyms

SCF I2
Pathway

Proteasome/Ubiquitin
Target

E3 Ubiquitin Ligase
Recptor

E3 Ubiquitin Ligase
Research Area

——
Indication

——

Chemical Information

CAS Number

99827-46-0
Formula Weight

342.35
Molecular Formula

22H14O4
Purity

>98% (HPLC)
Solubility

——
SMILES

C1=CC=C2C(=C1)C=CC(=C2C3=C(C=CC4=CC=CC=C43)C(=O)O)C(=O)O
Chemical Name

1-(2-carboxynaphth-1yl)-2-naphthoic acid

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Orlicky S, et al. Nat Biotechnol. 2010 Jul;28(7):733-7.

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