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HOIPIN-1

CAS No. ——

HOIPIN-1( JTP-0819958 | HOIP inhibitor-1 )

Catalog No. M17007 CAS No. ——

HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=2.8 uM).

Purity : >98% (HPLC)

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Biological Information

Product Name

HOIPIN-1
Note

Research use only, not for human use.
Brief Description

HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=2.8 uM).
Description

HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=2.8 uM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pathway.
In Vitro

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In Vivo

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Synonyms

JTP-0819958 | HOIP inhibitor-1
Pathway

Proteasome/Ubiquitin
Target

E3 Ubiquitin Ligase
Recptor

E3 Ubiquitin Ligase
Research Area

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Indication

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Chemical Information

CAS Number

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Formula Weight

304.277
Molecular Formula

C17H13NaO4
Purity

>98% (HPLC)
Solubility

——
SMILES

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Chemical Name

Sodium (E)-2-(3-(2-methoxyphenyl)-3-oxoprop-1-en-1-yl)benzoate

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Katsuya K, et al. Biochem Biophys Res Commun. 2019 Jan 2. pii: S0006-291X(18)32846-8. 2. Katsuya K, et al. SLAS Discov. 2018 Dec;23(10):1018-1029.

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