CI-947

Research use only, not for human use.

An orally active adenosine receptor agonist that can induce acute cardiovascular toxicity and coronary vascular injury in vivo.

An orally active adenosine receptor agonist that can induce acute cardiovascular toxicity and coronary vascular injury in vivo.

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PD 117519 (2-10 mg/kg; oral administration; 16-24 hours; male beagle dogs) treatment produces significant hemodynamic changes at Tmax (4 hours) follows by acute coronary vascular injury that is evident at 16 hours postdosing.Treatment with 2 or 10 mg/kg of PD 117519 produces significant increases in mean heart rate and decreases in mean indirectsystolic blood pressure at time of highest drug exposure, 4 hours postdosing. Animal Model:24 male beagle dogs (8-12 months old)Dosage:2 mg/kg or 10 mg/kg Administration:Oral administration; 16 hours and 24 hours Result:Increased in mean heart rate and decreased in mean indirectsystolic blood pressure at time of highest drug exposure. Induced acute coronary arteriopathy. The endothelium also appears injured.

PD-117519 | PD 117519 | PD117519 | CI 947 | CI947

Apoptosis

Adenosine Receptor

Adenosine Receptor

Neurological Disease

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96392-15-3

383.4012

C19H21N5O4

>98% (HPLC)

DMSO: ≥ 3.9 mg/mL

C1CC2=CC=CC=C2C1NC3=C4C(=NC=N3)N(C=N4)C5C(C(C(O5)CO)O)O

Adenosine, N-[(1R)-2,3-dihydro-1H-inden-1-yl]-

(-20℃)

With Ice Pack

≥ 2 years