BI605906( BI-605906 )

Catalog No. M16854 CAS No. 960293-88-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BI605906
Note

Research use only, not for human use.
Brief Description

BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP).
Description

BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK; inhibits TNF-α-dependent IκB degradation and expression of proinflammatory mediators interleukin-6, interleukin-1β, and CXCL1/2 in vivol; partially inhibits the IL-1-stimulated activation of IKKε/TBK1.
In Vitro

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In Vivo

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Synonyms

BI-605906
Pathway

Immunology/Inflammation
Target

IκB kinase (IKK)
Recptor

IκB kinase (IKK)
Research Area

Inflammation/Immunology
Indication

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CAS Number

960293-88-3
Formula Weight

432.5084
Molecular Formula

C17H22F2N4O3S2
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 29 mg/mL
SMILES

O=C(C1=C(N)C2=C(C(F)(F)CC)C=C(N3CCC(S(=O)(C)=O)CC3)N=C2S1)N
Chemical Name

Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]-

1. Clark K, et al. Biochem J. 2011 Feb 15;434(1):93-104. 2. Cameron AR, et al. Circ Res. 2016 Aug 19;119(5):652-65.

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