IKK2-IN-4( —— )

Catalog No. M34854 CAS No. 354811-10-2

IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

IKK2-IN-4
Note

Research use only, not for human use.
Brief Description

IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.
Description

IKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC50 of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Immunology/Inflammation
Target

IκB kinase (IKK)
Recptor

IκB/IKK | TNF
Research Area

——
Indication

——

Chemical Information

CAS Number

354811-10-2
Formula Weight

261.3
Molecular Formula

C12H11N3O2S
Purity

>98% (HPLC)
Solubility

——
SMILES

N(C(N)=O)C=1SC(=CC1C(N)=O)C2=CC=CC=C2
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Baxter A, et, al. Hit-to-lead studies: the discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2817-22.?

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