Cart
sales@molnova.com
Plocabulin
CAS No. 960210-99-5
Plocabulin( PM060184 | PM-060184 )
Catalog No. M16852 CAS No. 960210-99-5
Plocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 3123 | Get Quote |
|
| 50MG | 6282 | Get Quote |
|
| 100MG | 9000 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePlocabulin
-
NoteResearch use only, not for human use.
-
Brief DescriptionPlocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity.
-
DescriptionPlocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity, inhibits a panel of 23 tumor cell lines with GI50 of 20 pM-5 nM; inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells; also shows antifungal activity virtually abolishing growth of the filamentous fungus Aspergillus nidulans.
-
In Vitro——
-
In Vivo——
-
SynonymsPM060184 | PM-060184
-
PathwayCytoskeleton/Cell Adhesion Molecules
-
TargetMicrotubule/Tubulin
-
RecptorMicrotubule/Tubulin
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number960210-99-5
-
Formula Weight571.715
-
Molecular FormulaC31H45N3O7
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC[C@H]([C@@H]1CC=C(OC)C(O1)=O)/C=C(C)/C=C\C=C/C(N[C@H](C(N/C=C\C[C@@H](OC(N)=O)C/C=C\C)=O)C(C)(C)C)=O
-
Chemical Name[(1Z,4S,6Z)-1-[[(2S)-2-[[(2Z,4Z,6E,8S)-8-[(2S)-5-methoxy-6-oxo-2,3-dihydropyran-2-yl]-6-methylnona-2,4,6-trienoyl]amino]-3,3-dimethylbutanoyl]amino]octa-1,6-dien-4-yl] carbamate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Galmarini CM, et al. BMC Cancer. 2018 Feb 7;18(1):164.
2. Pantazopoulou A, et al. Sci Rep. 2018 Jun 5;8(1):8616.
3. Pera B, et al. ACS Chem Biol. 2013 Sep 20;8(9):2084-94.
4. Prota AE, et al. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13817-21.
molnova catalog
related products
-
CCB02
CCB02 (CCB 02) is a specific small molecule inhibitor of CPAP-tubulin interaction with IC50 of 0.689 uM in AlphaScreen assay.
-
Soblidotin
Soblidotin (Auristatin PE) is an inhibitor of tubulin polymerization. It is also a novel synthetic Dolastatin 10 derivative.
-
ABT-751
ABT-751 (E-7010) is an orally active antimitotic agent that inhibits tubulin polymerization.
