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Plocabulin

CAS No. 960210-99-5

Plocabulin( PM060184 | PM-060184 )

Catalog No. M16852 CAS No. 960210-99-5

Plocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Plocabulin
  • Note
    Research use only, not for human use.
  • Brief Description
    Plocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity.
  • Description
    Plocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity, inhibits a panel of 23 tumor cell lines with GI50 of 20 pM-5 nM; inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells; also shows antifungal activity virtually abolishing growth of the filamentous fungus Aspergillus nidulans.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PM060184 | PM-060184
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Microtubule/Tubulin
  • Recptor
    Microtubule/Tubulin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    960210-99-5
  • Formula Weight
    571.715
  • Molecular Formula
    C31H45N3O7
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C[C@H]([C@@H]1CC=C(OC)C(O1)=O)/C=C(C)/C=C\C=C/C(N[C@H](C(N/C=C\C[C@@H](OC(N)=O)C/C=C\C)=O)C(C)(C)C)=O
  • Chemical Name
    [(1Z,4S,6Z)-1-[[(2S)-2-[[(2Z,4Z,6E,8S)-8-[(2S)-5-methoxy-6-oxo-2,3-dihydropyran-2-yl]-6-methylnona-2,4,6-trienoyl]amino]-3,3-dimethylbutanoyl]amino]octa-1,6-dien-4-yl] carbamate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Galmarini CM, et al. BMC Cancer. 2018 Feb 7;18(1):164. 2. Pantazopoulou A, et al. Sci Rep. 2018 Jun 5;8(1):8616. 3. Pera B, et al. ACS Chem Biol. 2013 Sep 20;8(9):2084-94. 4. Prota AE, et al. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13817-21.
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