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BI 831266
CAS No. 958227-46-8
BI 831266( BI831266 )
Catalog No. M16845 CAS No. 958227-46-8
BI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBI 831266
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NoteResearch use only, not for human use.
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Brief DescriptionBI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM.
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DescriptionBI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM; inhibits the proliferation of human non-small cell lung cancer (NSCLC), pancreatic cancer, and prostate cancer cell lines (H460 tumor cell proliferation inhibition IC50=11 nM); causes tumor regression and growth inhibition in in murine xenograft tumor models (HCT 116 colon carcinoma, BxPC3 pancreatic adenocarcinoma, and NCI-H460 NSCLC).Solid Tumors Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsBI831266
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PathwayCell Cycle/DNA Damage
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TargetAurora Kinase
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RecptorAurora Kinase
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Research AreaCancer
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IndicationSolid Tumors
Chemical Information
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CAS Number958227-46-8
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Formula Weight528.098
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Molecular FormulaC27H38ClN7O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N(C)C1CCN(C)CC1)C2=CC=C(NC3=NC=C(Cl)C(N[C@H]4[C@@H](C(NC(C)C)=O)CCC4)=N3)C=C2
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Chemical Name4-((5-chloro-4-(((1R,2S)-2-(isopropylcarbamoyl)cyclopentyl)amino)pyrimidin-2-yl)amino)-N-methyl-N-(1-methylpiperidin-4-yl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dittrich C, et al. Invest New Drugs. 2015 Apr;33(2):409-22.
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