PI-3065( PI3065 | PI 3065 )

Catalog No. M16821 CAS No. 955977-50-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PI-3065
Note

Research use only, not for human use.
Brief Description

A potent inhibitor of PI3K p110δ with IC50/Ki values of 5/1.5 nM respectively.
Description

A potent inhibitor of PI3K p110δ with IC50/Ki values of 5/1.5 nM respectively; exhibits less potent activity against p110α, p110β, p110γ with IC50s of 910, 600, >10000 nM.
In Vitro

PI-3065 exhibits no inhibition of the growth of 4T1 cells, which do not express detectable levels of p110δ.
In Vivo

PI-3065 (75 mg/kg, p.o.) inhibits the growth of 4T1 tumours in the BALB/c mice without obvious body weight loss.
Synonyms

PI3065 | PI 3065
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

DNA-PK| mTOR| p110α| p110β| p110δ
Research Area

Inflammation/Immunology
Indication

——

CAS Number

955977-50-1
Formula Weight

506.638
Molecular Formula

C27H31FN6OS
Purity

>98% (HPLC)
Solubility

DMSO
SMILES

FC1=C(C2=NC(N3CCOCC3)=C4C(C=C(CN5CCN(CC6CC6)CC5)S4)=N2)C7=C(NC=C7)C=C1
Chemical Name

Thieno[3,2-d]pyrimidine, 6-[[4-(cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-

1. Ali K, et al. Nature. 2014 Jun 19;510(7505):407-11.

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