BMS-751324( BMS751324 )

Catalog No. M16791 CAS No. 948842-66-8

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Product Name

BMS-751324
Note

Research use only, not for human use.
Brief Description

BMS-751324 is a novel clinical prodrug of BMS-582949, which is a highly selective p38α MAPK inhibitor with IC50 of 13 nM.
Description

BMS-751324 is a novel clinical prodrug of BMS-582949, which is a highly selective p38α MAPK inhibitor with IC50 of 13 nM; BMS-751324 is effectively bioconverted into parent drug BMS-582949 in vivo by alkaline phosphatase and esterase in a stepwise manner; demonstrates similar efficacy in rat LPS-induced TNFα pharmacodynamic model and rat adjuvant arthritis model compared with BMS-582949; BMS-751324 is indeed effective in addressing the pH-dependent absorption issue associated with BMS-582949.
In Vitro

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In Vivo

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Synonyms

BMS751324
Pathway

MAPK/ERK Signaling
Target

p38 MAPK
Recptor

p38 MAPK
Research Area

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Indication

——

CAS Number

948842-66-8
Formula Weight

694.638
Molecular Formula

C32H35N6O10P
Purity

>98% (HPLC)
Solubility

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SMILES

CCCN(C(=O)C1=CN2C(=C1C)C(=NC=N2)NC3=C(C=CC(=C3)C(=O)NC4CC4)C)C(=O)OCOC(=O)CC5=CC=C(C=C5)OP(=O)(O)O
Chemical Name

(((4-((5-(cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyl)oxy)methyl 2-(4-(phosphonooxy)phenyl)acetate

1. Liu C, et al. J Med Chem. 2015 Oct 8;58(19):7775-84.

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