Cart
sales@molnova.com
Aumitin
CAS No. 946293-78-3
Aumitin( Aumitin )
Catalog No. M16783 CAS No. 946293-78-3
Aumitin is a novel potent autophagy inhibitor with IC50 of 124 and 244 nM against starvation- and rapamycin- induced autophagy respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 159 | In Stock |
|
| 5MG | 145 | In Stock |
|
| 10MG | 219 | In Stock |
|
| 25MG | 395 | In Stock |
|
| 50MG | 540 | In Stock |
|
| 100MG | 759 | In Stock |
|
| 200MG | 1004 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAumitin
-
NoteResearch use only, not for human use.
-
Brief DescriptionAumitin is a novel potent autophagy inhibitor with IC50 of 124 and 244 nM against starvation- and rapamycin- induced autophagy respectively.
-
DescriptionAumitin is a novel potent autophagy inhibitor with IC50 of 124 and 244 nM against starvation- and rapamycin- induced autophagy respectively, targets mitochondrial complex I; inhibits LC3 lipidation, and p62 degradation by starvation- as well as rapamycin-induced autophagy dose-dependently in MCF7-LC3 cells, suggesting inhibition of autophagic flux; inhibits mitochondrial respiration by targeting complex I with IC50 of 0.11 uM in HeLa cells; Aumitin is a new tool compound for interrogating autophagy and mitochondrial respiration by means of complex I inhibition.
-
In Vitro——
-
In Vivo——
-
SynonymsAumitin
-
PathwayAutophagy
-
TargetAutophagy
-
RecptorAutophagy
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number946293-78-3
-
Formula Weight429.908
-
Molecular FormulaC24H20ClN5O
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (232.61 mM)
-
SMILESO=C(NC1=CC=C(NC2=NC(NC3=CC=CC=C3)=CC(C)=N2)C=C1)C4=CC=CC=C4Cl
-
Chemical Name2-chloro-N-(4-((4-methyl-6-(phenylamino)pyrimidin-2-yl)amino)phenyl)benzamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Robke L, et al. Chem Sci. 2018 Feb 26;9(11):3014-3022.
molnova catalog
related products
-
Neriifolin
Neriifolin (17β-Neriifolin), a cardiac glycoside extracted from the unripe fruit of Cerbera manghas, is a Na+K+-ATPase inhibitor with anticancer activity that inhibits cell proliferation by suppressing HOXA9-dependent gene expression and inducing apoptosis in the human acute myeloid cell line, THP-1.
-
Glycycoumarin
Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.
-
GC7 Sulfate
GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so GC7 inhibits the activation of eIF5A2 by inhibiting DHS activity.
