SMER-18( SMER18 )

Catalog No. M16762 CAS No. 944153-47-3

COA

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Product Name

SMER-18
Note

Research use only, not for human use.
Brief Description

A small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein; reduces toxicity in Huntington's disease models.
Description

A small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein; reduces toxicity in Huntington's disease models.
In Vitro

——
In Vivo

——
Synonyms

SMER18
Pathway

Autophagy
Target

Autophagy
Recptor

Autophagy
Research Area

Neurological Disease
Indication

——

CAS Number

944153-47-3
Formula Weight

287.7409
Molecular Formula

C16H14ClNO2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

OC1=C2N=C(C)C=CC2=CC=C1C(NC3=NC=CC(C)=C3)C4=CC=CC=C4[N+]([O-])=O
Chemical Name

2-Buten-1-one, 1-(4-chlorophenyl)-3-[(3-hydroxyphenyl)amino]-, (2Z)-

1. Sarkar S, et al. Nat Chem Biol. 2007 Jun;3(6):331-8.

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