TH-237A( TH 237A | TH237A | meso-GS 164 )

Catalog No. M16689 CAS No. 935467-97-3

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Product Name

TH-237A
Note

Research use only, not for human use.
Brief Description

A novel, brain penetrant neuroprotective agent that protects neurons against β-amyloid (Aβ) induced neurotoxicity.
Description

A novel, brain penetrant neuroprotective agent that protects neurons against β-amyloid (Aβ) induced neurotoxicity; increases neuronal survival in the presence of the Aβ peptides in rat isolated neuronal culture with EC50 of 5 nM.
In Vitro

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In Vivo

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Synonyms

TH 237A | TH237A | meso-GS 164
Pathway

Others
Target

Amyloids
Recptor

Amyloids
Research Area

Neurological Disease
Indication

——

CAS Number

935467-97-3
Formula Weight

333.3293
Molecular Formula

C18H17F2NO3
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 46 mg/mL
SMILES

OC[C@@]12N([C@H](C3=CC=C(F)C=C3)OC2)[C@@H](C4=CC=C(F)C=C4)OC1
Chemical Name

1H,3H,5H-Oxazolo[3,4-c]oxazole-7a(7H)-methanol, 3,5-bis(4-fluorophenyl)-, (3R,5S)-rel-

1. Kelly E. Desino. Improving Blood Brain Barrier Permeation of Small Molecules Exhibiting Chemotherapeutic and Neuroprotective Effects.

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