BNC-1( BNC-1 | BNC 1 | BNC1 )

Catalog No. M16864 CAS No. 96335-59-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BNC-1
Note

Research use only, not for human use.
Brief Description

BNC-1 is a small molecule modulator of Amyloid pathology by promoting phosphorylation and activation of Elk-1.
Description

BNC-1 is a small molecule modulator of Amyloid pathology by promoting phosphorylation and activation of Elk-1, a transcriptional repressor of presenilin-1 but not presenilin-2; increases levels of synaptophysin and synapsin, markers of synaptic integrity, but does not adversely impact presenilin-2 or processing of Notch-1, significantly decreases amyloid burden and improves markers of synaptic integrity in a well-established mouse model of amyloid deposition.
In Vitro

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In Vivo

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Synonyms

BNC-1 | BNC 1 | BNC1
Pathway

Others
Target

Amyloids
Recptor

Amyloids
Research Area

——
Indication

——

CAS Number

96335-59-0
Formula Weight

282.299
Molecular Formula

C16H14N2O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C(C(C)=NC(C)=C12)=C2C3=CC=CC=C3NC1=O)OC
Chemical Name

Methyl 2,4-dimethyl-5-oxo-5,6-dihydrobenzo[c][2,7]naphthyridine-1-carboxylate

1. Lovell MA, et al. J Alzheimers Dis. 2016 May 4;53(1):273-87.

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