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FiVe1

CAS No. 932359-76-7

FiVe1( FiVe1 | FiVe 1 | FiVe-1 )

Catalog No. M16670 CAS No. 932359-76-7

FiVe1 is a vimentin binding small molecule that promotes vimentin disorganization and phosphorylation during metaphase.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	895	In Stock
5MG	758	In Stock
10MG	1036	In Stock
25MG	1568	In Stock
50MG	2074	In Stock
100MG	2725	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

FiVe1
Note

Research use only, not for human use.
Brief Description

FiVe1 is a vimentin binding small molecule that promotes vimentin disorganization and phosphorylation during metaphase.
Description

FiVe1 is a vimentin binding small molecule that promotes vimentin disorganization and phosphorylation during metaphase, causes mitotic catastrophe, multinucleation, and the loss of stemness in cancer cells; selectively and irreversibly inhibits the growth of mesenchymally transformed breast cancer cells ( FOXC2-HMLER cells IC50=234 nM) and soft tissue sarcomas of diverse histological subtypes.
In Vitro

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In Vivo

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Synonyms

FiVe1 | FiVe 1 | FiVe-1
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Microtubule/Tubulin
Recptor

Microtubule/Tubulin
Research Area

——
Indication

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Chemical Information

CAS Number

932359-76-7
Formula Weight

359.254
Molecular Formula

C18H16Cl2N4
Purity

>98% (HPLC)
Solubility

——
SMILES

ClC1=CC(N2CCN(C3=C4C=CC=C(Cl)C4=NN=C3)CC2)=CC=C1
Chemical Name

8-chloro-4-(4-(3-chlorophenyl)piperazin-1-yl)cinnoline

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Bollong MJ, et al. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912.

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