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FiVe1

CAS No. 932359-76-7

FiVe1( FiVe1 | FiVe 1 | FiVe-1 )

Catalog No. M16670 CAS No. 932359-76-7

FiVe1 is a vimentin binding small molecule that promotes vimentin disorganization and phosphorylation during metaphase.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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25MG	1485	Get Quote
50MG	2007	Get Quote
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Biological Information

Product Name

FiVe1
Note

Research use only, not for human use.
Brief Description

FiVe1 is a vimentin binding small molecule that promotes vimentin disorganization and phosphorylation during metaphase.
Description

FiVe1 is a vimentin binding small molecule that promotes vimentin disorganization and phosphorylation during metaphase, causes mitotic catastrophe, multinucleation, and the loss of stemness in cancer cells; selectively and irreversibly inhibits the growth of mesenchymally transformed breast cancer cells ( FOXC2-HMLER cells IC50=234 nM) and soft tissue sarcomas of diverse histological subtypes.
In Vitro

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In Vivo

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Synonyms

FiVe1 | FiVe 1 | FiVe-1
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Microtubule/Tubulin
Recptor

Microtubule/Tubulin
Research Area

——
Indication

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Chemical Information

CAS Number

932359-76-7
Formula Weight

359.254
Molecular Formula

C18H16Cl2N4
Purity

>98% (HPLC)
Solubility

——
SMILES

ClC1=CC(N2CCN(C3=C4C=CC=C(Cl)C4=NN=C3)CC2)=CC=C1
Chemical Name

8-chloro-4-(4-(3-chlorophenyl)piperazin-1-yl)cinnoline

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Bollong MJ, et al. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912.

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