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FiVe1
CAS No. 932359-76-7
FiVe1( FiVe1 | FiVe 1 | FiVe-1 )
Catalog No. M16670 CAS No. 932359-76-7
FiVe1 is a vimentin binding small molecule that promotes vimentin disorganization and phosphorylation during metaphase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 895 | In Stock |
|
| 5MG | 758 | In Stock |
|
| 10MG | 1036 | In Stock |
|
| 25MG | 1568 | In Stock |
|
| 50MG | 2074 | In Stock |
|
| 100MG | 2725 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFiVe1
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NoteResearch use only, not for human use.
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Brief DescriptionFiVe1 is a vimentin binding small molecule that promotes vimentin disorganization and phosphorylation during metaphase.
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DescriptionFiVe1 is a vimentin binding small molecule that promotes vimentin disorganization and phosphorylation during metaphase, causes mitotic catastrophe, multinucleation, and the loss of stemness in cancer cells; selectively and irreversibly inhibits the growth of mesenchymally transformed breast cancer cells ( FOXC2-HMLER cells IC50=234 nM) and soft tissue sarcomas of diverse histological subtypes.
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In Vitro——
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In Vivo——
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SynonymsFiVe1 | FiVe 1 | FiVe-1
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetMicrotubule/Tubulin
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RecptorMicrotubule/Tubulin
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Research Area——
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Indication——
Chemical Information
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CAS Number932359-76-7
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Formula Weight359.254
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Molecular FormulaC18H16Cl2N4
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Purity>98% (HPLC)
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Solubility——
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SMILESClC1=CC(N2CCN(C3=C4C=CC=C(Cl)C4=NN=C3)CC2)=CC=C1
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Chemical Name8-chloro-4-(4-(3-chlorophenyl)piperazin-1-yl)cinnoline
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bollong MJ, et al. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912.
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