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R 59022
CAS No. 93076-89-2
R 59022( R 59-022 | R59022 )
Catalog No. M16660 CAS No. 93076-89-2
A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 2.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 69 | In Stock |
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| 5MG | 68 | In Stock |
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| 10MG | 122 | In Stock |
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| 25MG | 283 | In Stock |
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| 50MG | 462 | In Stock |
|
| 100MG | 758 | In Stock |
|
| 200MG | 1004 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameR 59022
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 2.8 uM.
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DescriptionA small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 2.8 uM, inhibits the phosphorylation of OAG to OAPA with IC50 of 3.8 uM in intact platelets; concomitantly stimulates PKC activity, selectively suppresses U46619-induced enhancement of mouse portal vein contraction under high glucose conditions; also induces caspase-mediated apoptosis in glioblastoma cells and in other cancers, but lacks toxicity in noncancerous cells.
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In VitroWestern Blot Analysis Cell Line:HeLa cells Concentration:40 uM Incubation Time:30 min Result:Increased the phosphorylation of PKC downstream targets by about 2.5-fold.
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In VivoAnimal Model:SCID mice implanted with U87 GBM cells Dosage:10 mg/kg Administration:Intraperitoneal injection (i.p.) Result:Increased median survival and decreased tumor volume.
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SynonymsR 59-022 | R59022
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PathwayOthers
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TargetDGK
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RecptorDGK
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Research Area——
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Indication——
Chemical Information
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CAS Number93076-89-2
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Formula Weight459.58
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Molecular FormulaC27H26FN3OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (135.99 mM)
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SMILESO=C1C(CCN2CC/C(CC2)=C(C3=CC=C(F)C=C3)\C4=CC=CC=C4)=C(C)N=C5N1C=CS5
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Chemical Name6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dominguez CL, et al. Cancer Discov. 2013 Jul;3(7):782-97.
2. de Chaffoy de Courcelles DC, et al. J Biol Chem. 1985 Dec 15;260(29):15762-70.
3. Nunn DL, et al. Biochem J. 1987 May 1;243(3):809-13.
4. Nobe K, et al. Br J Pharmacol. 2004 Sep;143(1):166-78.
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