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R-59949
CAS No. 120166-69-0
R-59949( R59949 | R 59949 )
Catalog No. M10724 CAS No. 120166-69-0
A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10 uM in isolated platelet membranes and in intact platelets.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 87 | In Stock |
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| 2MG | 48 | In Stock |
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| 5MG | 80 | In Stock |
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| 10MG | 141 | In Stock |
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| 25MG | 297 | In Stock |
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| 50MG | 440 | In Stock |
|
| 100MG | 646 | In Stock |
|
| 200MG | 913 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameR-59949
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NoteResearch use only, not for human use.
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Brief DescriptionA small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10 uM in isolated platelet membranes and in intact platelets.
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DescriptionA small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10 uM in isolated platelet membranes and in intact platelets; markedly increases PKC activity in platelets stimulated with vasopressin, produces partial inhibition of formation of phosphatidic acid in human platelets challenged with thrombin, DC8 or OAG; also induces caspase-mediated apoptosis in glioblastoma cells and in other cancers, but lacks toxicity in noncancerous cells.
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In Vitro——
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In Vivo——
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SynonymsR59949 | R 59949
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PathwayOthers
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TargetDGK
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RecptorDGK
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Research Area——
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Indication——
Chemical Information
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CAS Number120166-69-0
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Formula Weight489.585
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Molecular FormulaC28H25F2N3OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (204.26 mM)
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SMILESO=C1N(CCN2CC/C(CC2)=C(C3=CC=C(F)C=C3)\C4=CC=C(F)C=C4)C(NC5=C1C=CC=C5)=S
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Chemical Name3-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dominguez CL, et al. Cancer Discov. 2013 Jul;3(7):782-97.
2. de Chaffoy de Courcelles D, et al. J Biol Chem. 1989 Feb 25;264(6):3274-85.
3. Rodríguez-Li?ares B, et al. Biochem Pharmacol. 1991 Mar 1;41(5):835-8.
4. Jiang Y, et al. Biochem Pharmacol. 2000 Apr 1;59(7):763-72.
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