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RG7713
CAS No. 920022-47-5
RG7713( RO-5028442 | RG-7713 )
Catalog No. M16602 CAS No. 920022-47-5
RG7713 (RO5028442, RG-7713) is a potent, highly selective, brain-penetrant vasopressin 1a (hV1a receptor) antagonist with Ki of 1 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 109 | In Stock |
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| 10MG | 190 | In Stock |
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| 25MG | 320 | In Stock |
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| 50MG | 480 | In Stock |
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| 100MG | 692 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameRG7713
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NoteResearch use only, not for human use.
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Brief DescriptionRG7713 (RO5028442, RG-7713) is a potent, highly selective, brain-penetrant vasopressin 1a (hV1a receptor) antagonist with Ki of 1 nM.
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DescriptionRG7713 (RO5028442, RG-7713) is a potent, highly selective, brain-penetrant vasopressin 1a (hV1a receptor) antagonist with Ki of 1 nM, shows no activiity on hV2 receptor (Ki>30 uM); displays moderate mouse affinity and excellent selectivity versus hV2 and hOT receptors.Other Indication Phase 1 Clinical(In Vitro):RG7713 (RO5028442) (compound 8) has excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. RG7713 (RO5028442) shows high solubility. RG7713 (RO5028442) is found to be highly selective against a panel of 89 targets. Finally, RG7713 (RO5028442) is identified as a suitable compound for clinical studies.
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In VitroRG7713 (RO5028442) (compound 8) has excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. RG7713 (RO5028442) shows high solubility. RG7713 (RO5028442) is found to be highly selective against a panel of 89 targets. Finally, RG7713 (RO5028442) is identified as a suitable compound for clinical studies.
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In Vivo——
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SynonymsRO-5028442 | RG-7713
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PathwayGPCR/G Protein
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TargetVasopressin Receptor
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RecptorhV1areceptor|mV1areceptor
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number920022-47-5
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Formula Weight437.97
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Molecular FormulaC25H28ClN3O2
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C(C1=CN(CCN(C)C)C2=C1C=CC(Cl)=C2)N3CCC4(CC3)OCC5=C4C=CC=C5
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Chemical Name(6-Chloro-1-(2-(dimethylamino)ethyl)indol-3-yl)-spiro(1H-isobenzofuran-3,4'-piperidine)-1'-yl-methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ratni H, et al. J Med Chem. 2015 Mar 12;58(5):2275-89.
2. Umbricht D, et al. Neuropsychopharmacology. 2017 Aug;42(9):1914-1923.
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