Smoothened Agonist (SAG)( Smoothened Agonist )

Catalog No. M16550 CAS No. 912545-86-9

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HNMR

HPLC

MSDS

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Product Name

Smoothened Agonist (SAG)
Note

Research use only, not for human use.
Brief Description

SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM).
Description

SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM).
In Vitro

——
In Vivo

Animal Model:Pregnant C57BL/6J mice Dosage:15, 17, 20 mg/kg Administration:A single i.p.Result:Effective in ca. 80% of the embryos and increased Gli1 and Gli2 mRNA expression in the limb bud, with Gli1 mRNA being the most upregulated at the dose of 20 mg/kg.
Synonyms

Smoothened Agonist
Pathway

GPCR/G Protein
Target

Hedgehog (Hh)
Recptor

Smoothened
Research Area

Cancer
Indication

——

CAS Number

912545-86-9
Formula Weight

490.06
Molecular Formula

C28H28ClN3OS
Purity

>98% (HPLC)
Solubility

Ethanol: 40 mg/mL warmed (75.97 mM); Water: 100 mg/mL (189.92 mM); DMSO: 71 mg/mL warmed (134.84 mM)
SMILES

CNC1CCC(CC1)N(CC1=CC=CC(=C1)C1=CC=NC=C1)C(=O)C1=C(Cl)C2=CC=CC=C2S1
Chemical Name

——

1.Chen JK, et al. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6.

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